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Investigations into SCAMP5, a candidate lupus risk gene expressed in plasmacytoid dendritic cells
Internal Dataset- Authors
- Mustafa GhanemAndrew ShihHimanshu VashisthaLatanya Coke4 more author(s)...
- Description
Objective: We have investigated the molecular function of SCAMP5, a candidate risk gene for SLE exclusively expressed in plasmacytoid dendritic cells (pDCs) among peripheral leucocytes. Methods: We tested the independence of the association in SCAMP5 with SLE by performing conditional analyses. We profiled the expression pattern of SCAMP5 among circulating leucocytes at the transcript and protein...
- Subject
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Dendritic CellsLupus Erythematosus, SystemicMembrane ProteinsRNA-Seq
- Access Rights
- Free to All
- Local Expert
- Andrew ShihPeter Gregersen
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IRF5 genetic risk variants drive myeloid-specific IRF5 hyper-activation and pre-symptomatic SLE
Internal Dataset- Authors
- Dan LiBharati MattaSu SongVictoria Nelson5 more author(s)...
- Description
The IRF5-SLE risk haplotype is associated with SLE disease severity. We hypothesized that neutrophils from healthy risk donors would carry a pathogenic gene signature compared to non-risk donors. To compare basal neutrophil gene signature between risk and non-risk healthy individuals, fresh whole blood was collected from healthy donors, and granulocytes were extracted from the remaining pellet following...
- Subject
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Genetic Predisposition to DiseaseGenetic VariationInterferon Regulatory FactorsLupus Erythematosus, Systemic
- Access Rights
- Free to All
- Local Expert
- Betsy BarnesPeter Gregersen